Denver Broncos at Los Angeles Chargers odds, picks and prediction

Jess Root
| Sportsbook Wire

The Denver Broncos (5-9) and Los Angeles Chargers (5-9) play a traditional AFC West rivalry game Sunday in Week 16, although it is without any playoff implications. Kickoff is at 4:05 p.m. ET at SoFi Stadium in Inglewood, Calif. Below, we preview the Broncos-Chargers betting odds and lines and make our NFL picks and predictions.

Broncos at Chargers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 7:22 p.m. ET.

  • Money line : Broncos +160 (bet $100 to win $160) | Chargers -190 (bet $190 to win $100)
  • Against the spread/ATS : Broncos +3.5 (-110) | Chargers -3.5 (-110)
  • Over/Under : 48.5 (O: -115 | U: -105)

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Broncos at Chargers: Game notes

  • Chargers QB Justin Herbert is having a fantastic rookie season. He has 3,781 passing yards and 27 touchdown passes against 10 interceptions, and he has rushed for 199 yards and four scores.
  • The Chargers have won two straight games.
  • The Broncos won the earlier matchup between the two teams, a 31-30 home victory on the final play of the game.
  • The Broncos have the fifth-worst scoring offense in the league, averaging only 19.7 points per game. They have scored over 19 points once in the last four games.
  • The Chargers have the eighth-worst scoring defense in the league, giving up 27.8 points per contest.

Broncos at Chargers: Key injuries

Broncos

  • LB Bradley Chubb (ankle) questionable
  • CB Nate Hairston (toe) questionable
  • RB Phillip Lindsay (hip, knee) out
  • DL Deshawn Williams (knee) questionable

Chargers

  • WR Keenan Allen (hamstring) questionable
  • DE Joey Bosa (shin, concussion) out
  • LB Denzel Perryman (back) questionable
  • TE Hunter Henry (COVID-19 reserve) out
  • DE Uchenna Nwosu (knee) out

Broncos at Chargers: Odds, betting lines, predictions and picks

Prediction

Chargers 27, Broncos 20

Money line ( ?)

The Chargers are coming off two straight wins and the Broncos have lost three of four. Having already lost to Denver earlier this season, the Chargers will want to pick up a home win. Both teams could be missing their top pass rusher and Denver will be missing its top running back. Expect a Chargers win at home to drop Denver to last place in the AFC West. Take the CHARGERS -190.

Against the spread ( ?)

Neither team has been a good bet ATS. Denver is 8-6 ATS, while Los Angeles is 7-7. The Chargers, though, have covered the spread in their last two games. Denver has been the underdog in every game it has played this season. Take the CHARGERS -3.5 ( -110).

Over/Under ( ?)

While the two teams combined for 61 points in their last meeting, this won’t be as high-scoring with both missing top offensive weapons. The Broncos are 2-4 O/U in their last six games, while the Chargers are 1-3 O/U in their last four. Take UNDER 48.5 ( -105).

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